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 VALIDUM

Validation of Bedside Ultrasound of Muscle Layer Thickness of the Quadriceps in the Critically Ill Patient: The VALIDUM Study

Objective :  To evaluate the validity of bedside ultrasounds (US) of quadriceps muscle layer thickness (QMLT) and Multiple Frequency Bioelectrical Impedance Analysis (MF-BIA) by comparing measurements from US and MF-BIA to those estimates of lean body mass obtained from CT scans of the abdomen when done for clinical reasons. 

Validum images

Valdium images 2

Hypothesis: We expect to observe a high degree of correlation between the baseline CT scan, US and MF-BIA and the changes in US measures and MF-BIA over time to correlate with changes to CT scan measures of lean body mass. 

Study Design:   This is a multi center, prospective, observation study across 5-6 intensive care units which will enroll 200 patients over a 12 month enrollment period followed by a 6 month period to complete data analysis.

Status: Erollment is complete.

Publication: Paris MT, Mourtzakis M, Day A, Leung R, Watharkar S, Kozar R, Earthman C, Kuchnia A, Dhaliwal R, Moisey L, Compher C, Martin N, Nicolo M, White T, Roosevelt H, Peterson S, Heyland DK. Validation of Bedside Ultrasound of Muscle Layer Thickness of the Quadriceps in the Critically Ill Patient (VALIDUM Study). JPEN J Parenter Enteral Nutr. 2017 Feb;41(2):171-180.

 

 

 

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