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PEP uP Protocol in Surgical Patients: A PEP uP RCT
Principal Investigator: Dr. Daniel Yeh (Massachusetts General Hospital)
Director, Clinical Evaluation Research Unit: Dr. Daren Heyland (Kingston General Hospital)
The PEP uP Protocol in Surgical Patients is the first PEP uP RCT to be conducted. The main objective of this RCT is to asses for safety, feasibility and effectiveness of an aggressive feeding protocol, the PEP uP (Enhanced Protein-Energy Provision via the Enteral Route Feeding) Protocol, in increasing protein and energy delivery to critically ill surgical patients. 

Funding: Nestle US

Status: Study is closed


Heyland DK, Murch L, Cahill N, McCall M, Muscedere J, Stelfox HT, Bray T, Tranquay T, Jiang X, Day AG. Enhanced protein-energy provision via the enteral route feeding protocol in critically ill patients (The PEP uP Protocol): Results of a cluster randomized trial. Crit Care Med 2013 Dec;41(12):2743-53 (PMID: 23982032)

For additional publications related to PEP uP please, go here

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