A Randomized Trial Of Supplemental Parenteral Nutrition in Under and Overweight Critically Ill Patients: The TOP UP Trial

Heyland DK et al.

The TOP UP trial was a pilot randomized controlled trial in 160 critically ill patients with a BMI of <25 or >35 in 8 ICUs across Canada, the United States and Europe. The purpose was to determine the effect of increased energy and protein amounts delivered to critically ill patients via enteral and parenteral nutrition. This pilot assessed the feasibility, recruitment rate, safety and tolerance of the intervention and also explored the effect of differential rates of energy/protein provision on muscle mass and muscle function.

Funded by: Canadian Intensive Care Foundation, Royal Alexandra Hospital Foundation, National Institutes of Health, and Baxter Healthcare Corp.

Status: Completed

Publication:  Wischmeyer PE, Hasselmann M, Kummerlen C, Kozar R, Kutsogiannis DJ, Karvellas CJ, Besecker B, Evans DK, Preiser JC, Gramlich L, Jeejeebhoy K, Dhaliwal R, Jiang X, Day AG, Heyland DK. A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial. Crit Care. 2017 Jun 9;21(1):142.