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Welcome to the 2018 Systematic Reviews by Critical Care Nutrition
In partnership with our colleagues at University Hospital RWTH Aachen in Germany, who have expertise in conducting systematic reviews, we have reviewed 51 topics on critical care nutrition. We have included all RCTs of nutritional interventions involving critically ill patients examining clinically important outcomes published since 1980. The included studies have undergone a formal review by our review committee and provide the latest and best summaries of evidence in the various areas of critical care nutrition.

Systematic reviews will be made available in December 2018 and January 2019. Refer to the topics below for a full list of the topics and for links to the available systematic reviews.

Review Committee:
Dr. Daren Heyland, MD
Dr. Christian Stoppe, MD

Supporting documents

Summary of Changes (2015 CPGs vs 2018 Systematic Reviews)

2018 Systematic Reviews, by topic

   1.0   The use of Enteral Nutrition vs Parenteral Nutrition (coming soon)
   2.0   Early vs. Delayed Nutrient Intake
   3.1   Indirect calorimetry vs. Predictive equations (Enteral Nutrition) 
   3.2   Achieving Target Dose of Enteral Nutrition  
   3.3a   Trophic vs Full Feeds  
   3.3b   Hypocaloric EN
   4.1a   Composition of EN: Diets with arginine and other nutrients
   4.1b(i)   Composition of EN: Fish oils, borage oils, & antioxidants
   4.1b(ii)   Composition of EN: Fish oils alone
   4.1c   Composition of EN: Immune Enhancing diets - Glutamine
   4.1d   Composition of EN: Immune Enhancing Diets - Ornithine KetoGlutarate (OKG)
   4.2a   Composition of EN: CHO/Fat: High fat/Low CHO
   4.2b   Composition of EN: CHO/Fat: Low fat/High CHO
   4.2c   Composition of EN: High Protein vs. Low Protein
   4.2d   Composition of EN: Fat Modified (new topic)
   4.3   Composition of EN: Protein/peptides
   4.4   Composition of EN: pH
   4.5   Fibre
   5.1   Feeding Protocols
   5.2a   Use of Motility Agents
   5.2b   Motility Agents vs Intestinal Feeding (new topic)
   5.3   Small Bowel vs. Gastric Feeding
   5.4   Body Position
   5.5   Gastric Residual Volumes (GRVs)
   5.6   Discarding Gastric Residual Volumes (GRVs)
   5.7   Fasting (new topic)
   6.1   Closed vs. Open Systems
   6.2   Enteral Nutrition: Prebiotics/Probiotics/Synbiotics
   6.3   Enteral Nutrition: Continuous vs. Other Methods of Administration
   6.4   Enteral Nutrition: Gastrostomy vs. Nasogastric Feeding
   6.5   Enteral Nutrition: Other Formulas
   7.1   Combination EN + PN (coming soon)
   7.2   Early vs. Delayed Supplemental PN
   8.0   Parenteral Nutrition vs. Standard Care
   9.1   Composition of PN: Branched Chain Amino Acids
   9.2   Composition of PN: Type of lipids (coming soon)
   9.3   Composition of PN: Zinc (alone or in combination) 
   9.4a   Composition of PN: Glutamine Supplementation
   9.4b   Composition of PN: Glutamine Supplementation + EN Supplementation
   9.4c   Composition of PN: EN + PN Glutamine
   9.5   Composition of PN: Protein and Amino Acids (new topic) (coming soon)
   10.1   Strategies to Optimize Parenteral Nutrition: Dose of PN
   10.2   Use of lipids (coming soon)
   10.3   Mode of lipid delivery  
   10.4a   Optimal glucose control: Insulin therapy
   10.4b   Optimal glucose control: Carbohydrate restricted formula + insulin therapy
   11.1   Antioxidant Nutrients: Combined Vitamins and Trace Elements (coming soon)
   11.2   Antioxidant Nutrients: Parenteral Selenium (alone or in combination) (coming soon)
   11.3   Vitamin C
   12.0   Vitamin D (coming soon)
   13.0   Thiamine (new topic)


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